Members of the NASUWT teaching union have voted to take strike action in the ongoing bitter row over public sector pensions.
In total, 82% voted in favour of industrial action, which now means they are set to join a mass walkout by more than two million public sector workers on November 30.
Turnout for the ballot was more than 40%, the NASUWT said.
NASUWT general secretary Chris Keates said the union's members had voted "overwhelmingly to reclaim the classroom and their profession".
More than 220,000 teachers and school leaders took part in what was the union's first national ballot for over a decade.
The results showed that: 82% voted in favour of strike action; 91% voted in favour of action short of strikes.
Ms Keates said: "NASUWT members have voted overwhelmingly to reclaim the classroom and their profession in the face of relentless attacks on their working conditions, pensions and jobs."
Half of teachers have seriously considered leaving the profession in the last 12 months, Ms Keates said, and only the recession is preventing a "mass exodus".
A series of unions have already declared their ballot results, setting themselves on a collision course with the Government. They argue that reforms will leave them paying in more, working longer and receiving less when they retire. Ministers say changes must be made to public sector pensions to ensure they are sustainable for the future.
More than two million workers are now set to walk out on November 30 for a day of action co-ordinated by the TUC, which will disrupt schools, courts, government offices, jobcentres, driving tests, council services and hospitals.